5-Hydroxytryptophan (5-HTP)

Studied for: Depression

Depression

What the research found

Therapeutic efficacy across mood and motor disorders. Meta-analyses of randomized trials report that 5-HTP can produce improvements in mood ratings and depressive symptom scores.

Dose used in studies

50 to 300 mg daily

Side effects reported

dose dependent gastric discomfort and diarrhea

References

Sutanto2024, Adekunle2025, Maffei2020

Not medical advice

Trials are run on specific people, for specific reasons, over a set period. Your medications, conditions and bloodwork can change what is safe for you. Ask a doctor or pharmacist before starting.