St. John's Wort
Studied for: Depression · Perimenopause
Depression
What the research found
(Hypericum perforatum) Proven effective for mild-to-moderate depression; performs comparably to prescription SSRIs with fewer side effects. Mechanism: Inhibits neurotransmitter reuptake. ⚠️ Warning: Induces CYP3A4 enzymes; has severe drug interactions with birth control, anticoagulants, and other antidepressants (risking serotonin syndrome).
Dose used in studies
900 to 1800 mg daily,
Side effects reported
mild gastric distress
References
Not yet listed
Perimenopause
What the research found
(Hypericum perforatum): Supported by clinical trials and systematic reviews for easing mild-to-moderate depression, anxiety, and mood swings tied to the menopausal transition. (Note: It interacts with many prescription drugs).
References
Not yet listed
Not medical advice
Trials are run on specific people, for specific reasons, over a set period. Your medications, conditions and bloodwork can change what is safe for you. Ask a doctor or pharmacist before starting.