Vitamin E
Studied for: Fatty Liver Disease · Hypercholesterolemia · Inflammation
Fatty Liver Disease
What the research found
The clearest therapeutic efficacy for vitamin E appears in non-alcoholic fatty liver disease and steatohepatitis. Umbrella meta-analyses demonstrate that doses exceeding 600 IU daily taken for at least 12 months significantly improve steatosis, lobular inflammation, and hepatic fibrosis stages. Significantly lowers ALT (ES -6.47) and AST (ES -5.35) and improves fibrosis scores (OR = 1.96)
Dose used in studies
600 IU daily
Side effects reported
well tolerated
References
Wang2023, Abdel-Maboud2020
Hypercholesterolemia
What the research found
Reduced total cholesterol (-5.20 mg/dL) and LDL-C (-4.21 mg/dL), with non-linear dose effects. Meta-analysis of 28 RCTs in diabetic adults.
Dose used in studies
400 IU daily
Side effects reported
well tolerated
References
Karimi2025
Inflammation
What the research found
Significantly reduces CRP (-0.52 mg/L) and suppresses TNF-α at doses ≥700 mg/day. Meta-analysis of 33 RCTs (n=2,102).
Dose used in studies
700 mg/day
Side effects reported
well tolerated
References
Asbaghi2020
Not medical advice
Trials are run on specific people, for specific reasons, over a set period. Your medications, conditions and bloodwork can change what is safe for you. Ask a doctor or pharmacist before starting.